Studies related to endothelial cell pathobiology and cardiovascular disease are well represented in AJP, which has topic categories in Cardiovascular, Pulmonary, and Renal Pathology, as well Vascular Biology, Atherosclerosis, and Endothelium Biology. This collection includes original research articles as well as some review articles in the field that have attracted exceptional attention. The full text of these articles is free to all readers. Also free to enjoy are eight review articles by experts in the field that appeared in the November 2021 Small Blood Vessel Disease in the Brain Theme Issue (https://ajp.amjpathol.org/issue/S0002-9440(21)X0010-7).