Animal Models of Disease

This compendium gathers studies in which animal models were essential to uncovering mechanisms of disease; indeed, the majority of articles in AJP make use of animal models. All of these papers are available without charge, with many having been designated Editor’s Choice articles for their exceptional significance and impact.

Curated Collections From The American Journal of Pathology
A Guide for the Use of the Ferret Model for Influenza Virus Infection
Phenotypic Characterization and Comparison of Cystic Fibrosis Rat Models Generated Using CRISPR/Cas9 Gene Editing
Quantification of Viral and Host Biomarkers in the Liver of Rhesus Macaques: A Longitudinal Study of Zaire Ebolavirus Strain Kikwit (EBOV/Kik)
Decreased Proteasomal Function Induces Neuronal Loss and Memory Impairment
Tumor Necrosis Factor Directs Allograft-Related Innate Responses and Its Neutralization Improves Hepatocyte Engraftment in Rats
Acute Respiratory Distress in Aged, SARS-CoV-2–Infected African Green Monkeys but Not Rhesus Macaques
Early Inflammation in Muscular Dystrophy Differs between Limb and Respiratory Muscles and Increases with Dystrophic Severity
Administration of a CXC Chemokine Receptor 2 (CXCR2) Antagonist, SCH527123, Together with Oseltamivir Suppresses NETosis and Protects Mice from Lethal Influenza and Piglets from Swine-Influenza Infection
YAP Accelerates Notch-Driven Cholangiocarcinogenesis via mTORC1 in Mice
Multiple Lesions Contribute to Infertility in Males Lacking Autoimmune Regulator