Studies of diseases that affect the nervous system have always found a welcoming home in the pages of The American Journal of Pathology. In fact, AJP’s immediate past Editor-in-Chief, Kevin Roth, is a renowned neuropathologist. This compendium brings together a sampling of articles in this field, which appear in topic categories such as Neurobiology and Tumorigenesis and Neoplastic Progression. These selections are freely available to all readers.