Pathobiology 2027

Myeloid cells including mononuclear phagocytes and granulocytes play central roles in the defense against invading pathogens and in maintaining homeostasis at mucosal barriers. However, their increased infiltration and exacerbated or defective activation emerges as a hallmark of chronic inflammatory and tumoral diseases. This season will cover hot topics in our understanding of these cells at digestive tissues, defining environmental cues that dictate their phenotypic diversity and the mechanisms that govern their interactions with key resident structural cells in the context of chronic inflammation.