Pathobiology 2027

This session delves into the molecular and cellular mechanisms underlying cardiovascular toxicity induced by anti cancer therapies, focusing on how targeted agents and chemotherapeutics disrupt cardiomyocyte signaling, mitochondrial integrity, and stress response pathways. Speakers will outline emerging frameworks that explain differential susceptibility to cardiac injury, including maladaptive kinase activation, oxidative stress, and metabolic dysfunction. This session also examines how lifestyle based interventions modulate these pathways, highlighting evidence that exercise holds value as an adjuvant therapy for attenuating treatment induced toxicity.