Pathobiology 2027

Multicellular organoid systems are rapidly expanding our ability to model human disease in physiologically relevant platforms. This session will highlight advances in organoid models across multiple organ systems, with invited presentations focused on human kidney organoids, liver disease organoid platforms, intestinal organoids for gastrointestinal disorders, and self-organizing cardiac organoids derived from pluripotent stem cells. A central theme of the session will be the use of organoid models as bridges between conventional cell culture, animal models, and human clinical disease. By incorporating multicellular architecture and organ-relevant biology, these platforms offer new opportunities to investigate disease mechanisms, evaluate therapeutic responses, screen candidate drugs, and develop more predictive preclinical models. This session will be of interest to experimental pathologists, cell and developmental biologists, stem cell researchers, translational scientists, and investigators seeking human-relevant systems for mechanistic disease studies and therapeutic testing.