Pathobiology 2027

Mechanisms of Disease

May 1-4, 2027

Flamingo Las Vegas, Las Vegas, NW

Session 008 – Biological Changes Induced in Space – Aging Connection with Cardiovascular Disease

3:00-4:45 PM
Sponsored by the ASIP Repair and Regeneration Scientific Interest Group and The Trivedi Institute for Space and Global Biomedicine at the University of Pittsburgh
Session Room: TBD

Session Co-Chairs

Wendy Mars

Wendy Mars, PhD
University of Pittsburgh School of Medicine

Andrew Duncan

Andrew Duncan, PhD
University of Pittsburgh School of Medicine

Session Overview

Spaceflight presents a unique environment that profoundly influences human biology, revealing fundamental mechanisms of tissue homeostasis, regeneration, aging, immunity, metabolism, and disease that are difficult or impossible to study on Earth. This session will highlight cutting-edge advances in space biomedicine, spanning molecular and cellular responses to the space environment, innovative experimental platforms, and emerging technologies that are transforming our understanding of human health in space. Speakers will discuss how discoveries made through spaceflight research are advancing precision medicine, regenerative medicine, and disease prevention while generating new insights with broad relevance to human health on Earth.

Agenda

  • Co-Chair – Welcome and Introductions

  • Afshin Beheshti3:00-3:25 PM
    How Space Biomedicine Research Will Benefit All People on Earth
    Afshin Beheshti, PhD
    University of Pittsburgh School of Medicine

  • Sylvain Costes3:25-3:50 PM
    Modeling Human Biological Responses to Spaceflight: From Immune Cell DNA Damage to Advanced Organoid Platforms
    Sylvain Costes, PhD
    University of Pittsburgh School of Medicine

  • Jonathan Schisler3:50-4:15 PM
    Friend or Foe? Epigenetic Control of CXCL5 in Spaceflight and Cardiovascular Disease
    Jonathan Schisler, PhD
    University of North Carolina