Webinar Archive

ASIP-HCS-ASMB Webinar: Family Life Balance in Science Careers: How to Balance It All?

October 26, 2022
12:00 PM Eastern Time (US and Canada)

This webinar aims to share the approach to finding family-life balance in science from a group of panelists at different career stages. We aim to share the common strategies people use to balance family and career while finding a sense of support from our scientific community. We will showcase how our common scientific endeavors relate to having a fulfilling personal life while building a stronger network and support.

Moderator: Roberto M. Mota Alvidrez, MD
Speakers:

• Diane Bielenberg, PhD, Boston Children's Hospital
• Jonathon Homeister, PhD, University of North Carolina
• Joanne Murphy-Ullrich, PhD, University of Alabama at Birmingham
• Scott Tanner, PhD, University of South Carolina Upstate

Breast Cancer Awareness Month Virtual Talk - An Update on Triple Negative Breast Cancer Therapeutics: Physician-Scientist and Patient Advocate Perspectives

October 13, 2022
12:00 PM Eastern Time

Dr. Goff will speak about current therapeutic strategies including immunotherapy in the treatment of triple negative breast cancer. Ms. Cook will talk about her experience of being diagnosed with invasive breast cancer and as a patient advocate.

Speakers:

• Clinician-Scientist: Dr. Stephanie L. Goff, MD, FACS Associate Research Physician
  National Cancer Institute, Surgery Branch, Center for Cancer Research
• Breast Cancer Advocate: Ms. Charmáine Cook
  Dana Farber Breast Cancer Patient Advocate

Career Options in Science - Industry vs Academia

July 27, 2022 12:00 PM (EDT)

Are you in academia wondering what if would be like to be an industry scientist? Are you in the industry contemplating a career move to academia? In a moderated discussion with a panel of mid to senior-level scientists with backgrounds in academia, industry, or both, we will compare and contrast the two professional environments. What are the tradeoffs? How do the environments differ? What strategies work best for navigating between the two? Other, career options such as government may also be discussed. Our panelists hail from ASIP, ASMB, and HCS in this our second tri-society webinar!

Moderators:

• Daisy Shu, PhD
  Schepens Eye Research Institute
• Vik Meadows, PhD
  Rutgers University

Panelists

Career Options in Science – Industry

Sponsored by the ASIP Pathology in Biotech and Industry SIG
July 13, 2022 12:00 PM (EDT)

Speakers

Alexis Scherl, MD, PhD
Genentech
Image Analysis in IBD

Abstract: While numerous histologic scoring systems for Ulcerative Colitis disease activity have been developed, they are difficult to reliably implement, and are subject to inter- and inter-pathologist variability. A robust, reproducible, and high-throughput image analysis algorithm for scoring tissue biopsies would be highly desirable in a clinical trial context. In a translational research context, image analysis can provide in-depth characterization of the content of and spatial relationships between cells and tissue features within biopsies; this data can be leveraged to test specific hypotheses or for biomarker discovery.

Shawn O'Neil, DVM, PhD
Pfizer
Use of Mass Spectrometry to Localize and Quantify Test Articles in Tissue Sections

Abstract: Mass spectrometry (MS) provides a label-free method for identifying molecules in tissues based upon their chemical signature rather than using indirect approaches, such as IHC and ISH which rely on antibodies and molecular probes, respectively. In toxicologic pathology, MS methods are being developed to localize and measure test articles and their metabolites in tissues and to correlate these spatially with microscopic findings in tissue sections. This presentation will provide fundamental descriptions of spatial applications of MS technology, including MALDI mass spectrometry imaging (MALDI-MSI) as well as the combined use of laser capture microdissection (LCM) with conventional mass spec analysis (LCMS) as an alternative method that provides identification and quantification of molecules with limited spatial context.

Navigating To and Through Mid-Career in Academic Science

Co-Sponsored by the American Society for Matrix Biology (ASMB) and The Histochemical Society (HCS)
June 29, 2022 12:00 PM (EDT)

The American Society for Investigative Pathology (ASIP) is pleased to be collaborating with The Histochemical Society (HCS) and the American Society for Matrix Biology (ASMB) for a series of career development e-Symposia. On June 29, we will focus on the daunting process of navigating from the early career to the mid-career phase in academia. We will discuss how to prepare for promotion and achieve it.

Topics will include:

• Mental resilience
• Dealing with the uncertainties of unstructured timelines of promotion
• How to staff and manage your lab
• How to know you have done "enough" to advance to the next level
• How to see yourself as worthy of a promotion

In addition, we will have the hard conversation about when to have kids if so desired, and what to do when your "plan" changes. We will also discuss what’s in store for folks in the mid-career stage of academia including new expectations and the committee tax often paid.

Our panelists hail from HCS, ASMB, and ASIP in this our first tri-society webinar! Our panelists are both folks who have recently navigated the transition to associate professor and experienced senior academic decision-makers and letter writers. Come join us to share your experience and lessons learned and/or discuss your concerns and gain guidance.

Panelists

The Biology Behind the PD-1 Checkpoint Blockade

Presented by 10X Genomics and the ASIP

Date: May 12, 2022
Time: 12:00 PM - 1:00 PM (ET)

Moderator:
Chhavi Chauhan, Ph.D., E.L.S, Director of Scientific Outreach, American Society for Investigative Pathology

Speaker:
Arlene Sharpe, MD, PhD
Chair & Professor, Department of Immunology
Harvard Medical School

Description: This webinar will focus on the functions of the PD-1 pathway and its inhibition as an immunotherapeutic approach. In addition, it will highlight the use of a CRISPR-based screening system for discovery of immunotherapy targets.

Key Learning Objectives: After attending this webinar, you will be able to:

• Describe the functions of PD-1 inhibitory signals.
• Understand the role of PD-1 pathway as a mediator of T cell exhaustion.
• Appreciate the use of PD-1 checkpoint inhibitors in tumor prevention/management.
• Understand the role of PD-1 signals in controlling primary influenza infection.
• Describe the use of a CRISPR-based screening system for discovery of immunotherapy targets

Recommended Reading:

• Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
• Reversing T-cell Dysfunction and Exhaustion in Cancer
• Memory T-Cell Heterogeneity and Terminology
• CD8 T cell exhaustion in Chronic Viral Infection and Cancer: Opportunities for Interventions
• The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

Rift Valley Fever: A Deadly Zoonotic Disease of Ruminants and Humans

Date: Thursday, December 16, 2021, 10:00 AM (EST)

Pathology in Biotech and Industry SIG Presents: Inside the ‘Black Box’ – How Pathology is Applied in Industry and How Industry Careers are Developed

Date: November 16

Session Description: Pathology as a scientific and clinical discipline has had increasing relevance in biotechnology and the pharmaceutical industry but is a career track that is often not considered or transparent to pathology trainees and early investigators. This panel discussion shines a light on this topic by providing real life examples of how pathology is being applied in industry and how careers are developed there. Panelists representing a variety of different industry settings and roles will each briefly present how pathology is applied in their unique work context and how their career track brought them to where they are now. A question and answer session will follow the presentations. This session provides trainees, young scientists, pathologists, and the members of the larger scientific community the opportunity to better understand pathology career opportunities in industry and to network with those already engaged in such careers.

Panelists:

• Cary D. Austin, MD, PhD, Senior Principal Pathologist & Biobanking Scientific Lead, Genentech Research Pathology (Session Co-Chair)
• Shawn P. O’Neil, DVM, PhD, Senior Director & Global Microscopic Imaging Lead, Pfizer Drug Safety Research & Development (Session Co-Chair)
• Reina Fuji, VMD, PhD, Senior Principal Pathologist & Director of Digital Pathology, Genentech Safety Assessment Pathology
• Keith Wharton Jr., MD PhD, Vice President, Medical Director, Ultivue, Inc.
• Suzana S. Couto, DVM, PhD, Senior Director, Head of Pathology, Genmab Inc.
• David A. Eberhard, MD PhD, Senior Medical Director (Oncology), Illumina Inc.
• Lauri J. Diehl, DVM, PhD, Dip ACVP, Executive Director, Pathobiology, Gilead Sciences
• Kate Hammerman, VMD, PhD, DACVP, Veterinary Pathologist/Associate Research Fellow, Pfizer Drug Safety Research & Development
• Susan V. Westmoreland, VMD, Senior Principal Pathologist, Abbvie, Immunology, Pharmacology Research & Development

Young Scientist Leadership Award Lecture

Morgan Preziosi, PhD • FENIX Group International
A Personal Story of Career Development – From Early-Stage Student to Starting a Career, and Navigating the Steps in Between

Date: April 27, 2021

Introduction: Satdarshan Paul Singh Monga, MD
University of Pittsburgh

Description: In this presentation, Dr. Preziosi will format her award lecture as a career development talk. She has always been passionate about helping earlier-stage trainees navigate their careers, and is hoping they can learn from her experiences. In the past few years her career has taken unexpected, but welcome, turns outside of her original career goals, and ASIP has been helping her every step of the way. Her talk will feature her experiences as a graduate student, postdoc, industry scientist, and now a life science consultant, and the advice and insight that she gathered at each stage. She hopes attendees will benefit from her talk regardless of their career stage and their current goals.

Rous-Whipple Award Lecture

George Perry, PhD • University of Texas at San Antonio
Pathology in Alzheimer Disease: A Protective Response?

Date: April 27, 2021

Introduction: Xiongwei Zhu, PhD
Case Western Reserve University

Outstanding Investigator Award Lecture

Jayanta Debnath, MD • University of California, San Francisco
Autophagy and Secretion in Cancer

Date: April 28, 2021

Introduction: Abul Abbas, MBBS
University of California, San Francisco

Cotran Early Career Investigator Award Lecture

Kari Nejak-Bowen, PhD, MBA • University of Pittsburgh
Therapeutic Implications of Modulating Beta-Catenin in Cholestasis

Date: April 30, 2021

Introduction: Satdarshan Paul Singh Monga, MD
University of Pittsburgh

Insights from Autopsy-Based Clinicopathological Correlation of COVID-19: Pathology, Mechanisms, and Treatment

Date: March 10, 2020

Description: Drs. Buja and Vander Heide discuss what we know and what remains to be elucidated about COVID-19.

Learning Objectives:

1. Discuss the epidemiology and major trends in the pandemic
2. Describe the key pathological findings in cases of severe COVID-19
3. Discuss implications of the pathological findings for pathophysiology and pathogenesis of the disease
4. Discuss implications of the pathological findings for therapy and prevention of the disease

Navigating Implicit Bias

Date: February 24, 2021

Description:
This session will emphasize the understanding of what implicit bias represents, how it affects interpersonal relationships and our daily life with a focus on having a conversation on how implicit bias affects scientific research in academia.

Learning objectives:

1. Identify implicit bias
2. Recognize the effects of implicit bias in everyday life and the implications it has in academia and industry
3. Identify the wide-range affects of implicit bias the relationship of implicit bias, and effective ways to understand our personal implicit bias

PISA 2020 ePoster Award Short Talks

Date: January 26, 2021

Featuring abstract-driven short talks given by:

Michele Alves, PhD
Ohio State University
“Newborn Innate Immunity Response Promotes Distinct Molecular Mechanisms of the Brainstem Neural Cell Population”

Karis Kosar, BA
University of Pittsburgh
“Wnt7b Beta-Catenin Independent Signaling Regulates Cholangiocyte Proliferation and Function During Cholestasis”

John Santiago, PhD
Brown University
“Mitochondrial Genotype Alters the Impact of Rapamycin on the Transcriptional Response to Nutrients in Drosophila”

Access Session Recording

PISA 2020 ePoster Award Short Talks

Date: January 28, 2021

Featuring abstract-driven short talks given by:

Kathryn Hendee, PhD
Medical College of Wisconsin
“Mechanosensitive Mechanism of Lung Regeneration through Endothelial YAP1”

Brendan Rooney,PhD
Georgetown University
“Using Bilateral Gaussian Denoising and Mean Pixel Intensity Measurement as a Computational Assay for Mouse Mammary Gland Density in Breast Cancer Risk Models”

Margarete Karg, PhD
Schepens Eye Research Institute of Mass Eye and Ear
“In Vivo Epigenetic Reprogramming to Reverse Age-Induced Retinal Pigment Epithelial Cell Dysfunction”

Exercise Oncology: Harnessing the Therapeutic Benefits of Exercise

ASIP Young Scientist Leadership Award Lecture

Date: November 18, 2020

Time: 11:30 AM (EDT)

Understanding Breast Cancer: My Journey as a Physician-Scientist

ASIP Outstanding Investigator Award Lecture

Date: November 11, 2020

Time: 10:00 AM (EDT)

Exploring Precision Oncology: From Gene Fusions to Genomic Instability

ASIP Rous-Whipple Award Lecture

Date: October 7, 2020

Time: 11:30 AM (EDT)

New Insights on Oxygen Sensing Signaling in Cancer

ASIP Cotran Young Investigator Award Lecture

Date: September 30, 2020

Time: 11:30 AM (EDT)

Convalescent Plasma: Donor Selection and Randomized Controlled Trial

Date: September 29, 2020

Time: 11:30 AM (EDT)

Description: This webinar will describe convalescent plasma and its use in treatment for COVID-19 patients. Additionally, the experts will discuss how they established safety and serological testing, qualified COVID 19 convalescent plasma (CCP) donors, and are conducting clinical trials to determine CCP effectiveness in COVID-19 patients.

Speakers:

• Dr. Eric Salazar (Medical Director of Coagulation Laboratories and Co-Medical Director of Transfusion Medicine, Houston Methodist Hospital)
• Dr. Krystalyn E. Hudson (Assistant Professor in the Department of Pathology and Cell Biology, Columbia University Irving Medical Center)
• Dr. James M. Musser (Fondren Presidential Distinguished Chair/Chair of the Department of Pathology and Genomic Medicine/Director of the Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute)
• Dr. Chhavi Chauhan (Director of Scientific Outreach/JMD CME Program, American Society for Investigative Pathology)

Access Session Recording: Coming Soon!

Branching Out: New Roles for the Parkinson’s Disease-Associated Kinase PINK1 in Synapto-Dendritic Neuroprotection

ASIP Robbins Distinguished Educator Award Lecture

Date: September 23, 2020

Time: 11:30 AM (EDT)

Access Session Recording: Coming Soon!

Weathering the Cytokine Storm in COVID-19

Date: September 18, 2020

Time: 11:30 PM (EDT)

Description: The ongoing coronavirus disease 2019 (COVID-19) pandemic continues to cause significant morbidity and mortality worldwide. COVID-19 symptoms, including systemic inflammatory response and multi-system organ failure, are now affecting thousands of SARS-CoV-2–infected patients and causing widespread mortality. Life-threatening “cytokine storms” involving the release of pro-inflammatory cytokines (e.g., tumor necrosis factor-α; interleukin-6, -1, and -8; and monocyte chemoattractant protein-1) may contribute to the rapid systemic organ failure observed in select critically ill COVID-19 patients. Therefore, controlling inflammatory responses to COVID-19 may be as important as anti-viral therapies. A paradigm shift is emerging in our understanding of the resolution of inflammation as an active biochemical process with the discovery of novel endogenous specialized pro-resolving lipid autacoid mediators (SPMs), such as resolvins. SPMs stimulate macrophage-mediated clearance of debris and counter pro-inflammatory cytokine production—a process collectively termed the resolution of inflammation. The role of resolution of inflammation in COVID-19 remains of interest. Mortality due to COVID-19 is strongly associated with cardiovascular disease, whereas COVID-19 itself can also induce myocardial injury, acute coronary syndrome, and venous thromboembolism.

Panelists: Dr. Dipak Panigraphy, Dr. Pilar Alcaide, and Dr. Charles Serhan
Moderator: Dr. Chhavi Chauhan

Access Session Recording: Coming Soon!

Pathology, Pathogenesis, and Implications for Treatment and Outcomes in COVID-19 Patients

Date: August 19, 2020

Time: 11:30 AM in Eastern Time

Description: This webinar will address the following:

1. The pathogenesis of SARS-CoV-2 disease based on properties of the virus and susceptibility factors in the host which influence the severity of disease
2. Disease expression in lungs, heart, and other organ systems
3. Mainline therapy for hypoxic respiratory failure
4. Rationale for potential adjunctive therapeutic options, including antivirals, antibodies, anti-inflammatory agents, targeted immunomodulatory therapies, anticoagulants, and antifibrotics
5. Vaccine development and prevention

Speakers:

• L. Maximilian Buja, MD (Professor of Pathology and Laboratory Medicine, McGovern Medical School of the University of Texas Health Science Center at Houston)
• Chhavi Chauhan, PhD, ELS (Director of Scientific Outreach/JMD CME Program, the American Society for Investigative Pathology)

Access Session Recording: Coming Soon!

Serological Testing for COVID-19

Date: July 29, 2020

Time: 11:30 AM in Eastern Time

Description: The Chairs of two academic Pathology departments will discuss their experience with SARS-CoV-2 antibody testing in the clinical laboratory, including methodology, utility, and open questions.

Speakers:

• Charles A. Parkos, MD, PhD (Carl V. Weller Professor and Chair of the Department of Pathology, University of Michigan Medical School)
• Peter E. Jensen, MD (Chair of the Department of Pathology at the University of Utah and Chair of the Board of Directors, ARUP Laboratories)
• Chhavi Chauhan, PhD, ELS (Director of Scientific Outreach/JMD CME Program, the American Society for Investigative Pathology)

Access Session Recording: Coming Soon!

Autopsy Insights into the Pathogenesis of COVID-19

Date: June 15, 2020

Description: Drs. Buja and Vander Heide will discuss up-to-date information regarding the pathobiology of COVID-19 based on their personal experiences conducting autopsies on COVID-19 positive patients in Houston, Texas and New Orleans, Louisiana, respectively. In addition, they will review information from autopsy series starting to emerge from other US cities as well as other countries. The speakers will present the actual evidence that COVID-19 is a systemic viral disease with multifaceted abnormalities of the lungs and the heart.

Speakers:

• L. Maximilian Buja, MD (Professor of Pathology and Laboratory Medicine, McGovern Medical School of the University of Texas Health Science Center at Houston)
• Richard Vander Heide, MD, PhD, MBA (Professor of Pathology, Louisiana State University Health Science Center)
• Chhavi Chauhan, PhD, ELS (Director of Scientific Outreach/JMD CME Program, the American Society for Investigative Pathology)

Access Session Recording: Coming Soon!

COVID-19 Molecular Testing: The Wild, Wild, West that Nobody Wanted

Date: June 8, 2020

Description: Drs. Tsongalis and Fernandes will discuss the challenges of implementing Emergency Use Authorization (EUA) testing for the detection of SARS-CoV-2 RNA during the recent COVID-19 pandemic. In addition, they will focus on the implementation and clinical utility of these EUA tests for the detection of SARS-CoV-2 RNA at laboratories in the epicenter of the COVID-19 pandemic.

Speakers:

• Helen Fernandes, PhD (Director, Personalized Genomic Medicine Laboratory, @Columbia University Medical Center)
• Gregory J. Tsongalis, PhD (Vice Chair for Research/Director of the Laboratory for Clinical Genomics and Advanced Technology (CGAT), Dartmouth Hitchcock Medical Center)
• Chhavi Chauhan, PhD, ELS (Director of Scientific Outreach/JMD CME Program, the American Society for Investigative Pathology)

Access Session Recording: Coming Soon!

Autopsy in the Time of COVID-19

Date: June 3, 2020

Description: Drs. Buja and Williamson will discuss and address the concerns surrounding the postmortem examination of COVID-19 decedents as well as the use of effective personal protective equipment while conducting these autopsies. In addition, the speakers will share their knowledge of the findings reported to date in decedents dying of or with COVID-19.

Speakers:

• L. Maximilian Buja, MD (Professor of Pathology and Laboratory Medicine, McGovern Medical School)
• Alex K. Williamson, MD (Chief of Autopsy Pathology/Director of Northwell Regional Autopsy Service, Northwell Health)
• Chhavi Chauhan, PhD, ELS (Director of Scientific Outreach/JMD CME Program, the American Society for Investigative Pathology)

Access Session Recording: Coming Soon!