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2016 2015 2014 2013

2016

New Study Questions the Safety of Caspase Inhibitors for the Treatment of Liver Disease
Although effective in preventing apoptosis, caspase inhibitors may lead to necrotic cell death, according to a report in The American Journal of Pathology.
October 2016

Cascade of Events Leading to Prion Disease Described
New experiments in mice now enable researchers to evaluate disease progression and potential therapeutic interventions in vivo, according to a new report in The American Journal of Pathology.
September 2016

Diabetes Reversal After Bypass Surgery Linked to Changes in Gut Microorganisms
Duodenum-jejunum gastric bypass surgery in diabetic mice results in changes in gut microbiota, improved metabolism, and diabetes remission, according to a new report in The American Journal of Pathology.
August 2016

Researchers at NIH Have Developed Simple, Sensitive, and Cost-Effective Assays for Analyzing Fragile X–Related Disorders
Tests useful for preclinical and clinical research on a genetic mutation related to autism and intellectual disability may become more available, reports The Journal of Molecular Diagnostics
August 12, 2016

New Mutation-Testing Technology Has Potential to Guide Targeted Therapies in Lung and Colorectal Cancers
Scientists demonstrate effectiveness of hybridization-induced aggregation technology to detect KRAS mutations in lung and colorectal cancers, reports The Journal of Molecular Diagnostics
June 8, 2016

New Study Lays Groundwork for Potential New Anti-Cancer Therapy
Identification of a lymphatic endothelium origin may enable development of targeted therapies for angiomyolipoma and lymphangioleiomyomatosis, according to a new report in The American Journal of Pathology.
July 2016

Intraocular Therapy Prevents or Reverses Diabetic Retinopathy in Mice
Agent leads to overexpression of angiotensin converting enzyme-2, according to a new report in The American Journal of Pathology.
June 2016

Novel Research Lays the Groundwork for New Therapies Against Sepsis
Protective role for SHARPIN, a protein involved in regulating inflammation, according to report in The American Journal of Pathology.
May 2016

New Assay Offers Improved Detection of Deadly Prion Diseases
Timed amyloid seeding assay achieves or surpasses sensitivity of currently available tests for transmissible spongiform encephalopathies, according to report in The Journal of Molecular Diagnostics
April 8, 2016

Serotonin Deficiency Implicated in Rheumatoid Arthritis
RA Symptoms and Pathology Worse in Mice Missing Enzyme Needed for Serotonin Synthesis, According to Report in The American Journal of Pathology.
March 9, 2016

New Assay Detects Persistent Disease in Leukemia Patients Thought to Be in Remission
Report in The Journal of Molecular Diagnostics Describes a More Sensitive and Personalized Method of Identifying Patients Likely to Relapse Compared to the Current Gold Standard
February 5, 2016

First Reported Autopsy of Patient with Middle East Respiratory Syndrome Coronavirus Infection Provides Critical Insights
Three years after first reported MERS-CoV death, long-awaited findings contradict previous assumptions and highlight the continuing importance of autopsies to understand disease, according to The American Journal of Pathology.
February 5, 2016

New Strategy Aims to Enhance Efficacy and Safety of Bone Repair Treatment: Better Quality Bone Growth Seen When NELL-1 Added to BMP2 Therapy
According to New Research Published in The American Journal of Pathology.
January 6, 2016


2015

Biochemical Clues May Predict Who Develops Alzheimer Disease-and Who Doesn't
According to New Research Published in The American Journal of Pathology.
December 21, 2015

Ethnic Differences in Cystic Fibrosis Genetic Coding Not Addressed in Screening Tests for Nonwhite Patients
Recommended Screening Test Reflects Genetic Variants Characteristic of White Populations, According to a Report in The Journal of Molecular Diagnostics
December 16, 2015

Genetic Modification Shows Promise for Preventing Hereditary Hearing Loss
Reducing Enzyme Activity in Mice with Mitochondrial Dysfunction Prevents or Delays Deafness, According to New Research Published in The American Journal of Pathology
November 6, 2015

Gut Microorganisms Cause Gluten-Induced Pathology in Mouse Model of Celiac Disease
Early Exposure to Antibiotics, Resulting in Microbial Imbalance, Exacerbates Response to Gluten, According to Research Published in The American Journal of Pathology
October 8, 2015

Study Lays Groundwork for Blood Test to Aid in the Detection and Monitoring of Myeloma
Serum MicroRNA Profiles Change as Myeloma Progresses, According to a Report in The Journal of Molecular Diagnostics
September 30, 2015

Placental Problems in Early Pregnancy Associated with 5-Fold Increase in Risk of Obstetric and Fetal Disorders
Increased Cell Death and Reduced Growth Promoting Factors Linked to the Early Pathology of Preeclampsia, Restricted Fetal Growth, and Stillbirth, According to Research Published in The American Journal of Pathology
September 16, 2015

Biomarker Helps Predict Survival Time in Gastric Cancer Patients
MicroRNA 506 Acts as a Suppressor of Angiogenesis and Metastasis in Gastric Cancer, According to Research Published in The American Journal of Pathology
September 8, 2015

New Strategy Improves Detection of Genetic Mutations in Hereditary Colorectal Cancer
Enhanced Accuracy and Reduced Turnaround Time of Testing Can Provide Vital Information for Patients Suspected of Having Lynch Syndrome and Their Family Members, According to a Report in The Journal of Molecular Diagnostics
August 27, 2015

Study Suggests New Treatment Avenue to Prevent Serous Retinal Detachment
Research Published in The American Journal of Pathology Points to Causal Role of Mast Cell Degranulation in Acute and Chronic Eye Problems
July 22, 2015

Genomic Testing Can Help Identify Patients at Heightened Risk for Esophageal Cancer
Endoscopic Samples Show Precancerous Genomic Changes in Barrett's Esophagus, According to Report in The Journal of Molecular Diagnostics
June 8, 2015

Cell Fusion Connects Oncogenesis with Tumor Evolution
"Genomic Catastrophe” May Cause Normal Cells to Become Cancerous Aberrant Cell Fusion May Initiate Cancerous Processes and Tumor Formation, According to a New Study Published in The American Journal of Pathology
June 8, 2015

Changes in Placenta's Protective Ability During Pregnancy Linked to Transporter Proteins
Results Clarify Why Bacterial Infections in First Trimester May Heighten Fetus' Vulnerability to Drugs and Toxins, According to Study Published in The American Journal of Pathology.
May 8, 2015

New Assay Helps Determine Lymphoma Subtypes Simply, Quickly, and Inexpensively
RT-MLPA Assay May Help Clinicians Evaluate Prognosis and Target Effective Therapies for Lymphoma Patients, According to Report in The Journal of Molecular Diagnostics
April 16, 2015

Increasing Evidence Points to Inflammation as Source of Nervous System Manifestations of Lyme Disease
Results Show that Anti-Inflammatories May Prevent Many Neuropathologic Effects of Lyme Neuroborreliosis, According to Study Published in The American Journal of Pathology.
April 16, 2015

Researchers Identify Potential Prognostic Marker for Recurrence of Head and Neck Squamous Cell Carcinoma
Molecular Profiling May Be Useful for Early Diagnosis and Treatment Decisions, According to Study Published in The American Journal of Pathology.
March 20, 2015

Amyloid Formation May Link Alzheimer Disease and Type 2 Diabetes
Islet Amyloid Peptide Found in Human Brain Senile Plaques with Beta-Amyloid, According to Study Published in The American Journal of Pathology. February 17, 2015

The Journal of Molecular Diagnostics Publishes Special Article Presenting the Laboratory Perspective of Incidental Findings Reporting
AMP Incidental Findings Working Group Recommends that Laboratories Develop Individual Policies for Analysis and Reporting of Known and Predicted Incidental Findings, According to Report in The Journal of Molecular Diagnostics
February 12, 2015

Crucial Protective Role Observed for Farnesoid-X Receptor in Cholestatic Liver Injury
The Oral FXR-Agonist INT-747 Normalizes Dysfunctional Intestinal FXR-Signaling and Changes in Intestinal Permeability, Inflammation, and Bacterial Translocation, According to Study Published in The American Journal of Pathology.
January 29, 2015

New Whole Blood Assay May Help Overcome Roadblocks to TB Eradication
Assay Accurately Differentiates Patients with Latent TB from those with Active Disease, According to Report in The Journal of Molecular Diagnostics
January 6, 2015

New Study Challenges Link between HLA Class I Hyperexpression in Pancreas and Type 1 Diabetes
Discrepancy Found between Results from Immunohistochemistry and from Quantitative Techniques, According to Study Published inThe American Journal of Pathology.
January 5, 2015


2014

Prognostic Role Found for miR-21 Expression in Triple-Negative Breast Cancer
Findings Suggest Measurement of Changes in the Tumor Microenvironment Are Important in this Heterogeneous Group, According to Study Published in The American Journal of Pathology
December 2, 2014

RESPECTED MOLECULAR PATHOLOGIST APPOINTED NEW EDITOR-IN-CHIEF OF THE JOURNAL OF MOLECULAR DIAGNOSTICS
October 23, 2014 - The editorial direction of The Journal of Molecular Diagnostics (JMD) is transferring to the stewardship of respected molecular pathologist Barbara A. Zehnbauer, Ph.D., FACMG, FACB, on January 1, 2015.

Presence of Enzyme May Worsen Effects of Spinal Cord Injury and Impair Long-term Recovery
Findings Suggest MMP-3 Disrupts Blood-Spinal Cord Barrier and Promotes Hemorrhage, According to Study Published in The American Journal of Pathology
October 16, 2014

Researchers Find RNA Molecules in Urine and Tissue That Detect Prostate Cancer
Potential Biomarkers May Pave Way to a More Sensitive, Specific, and Noninvasive Prostate Cancer Screening Assay, According to Report in The Journal of Molecular Diagnostics
October 9, 2014

Growth Factors Found in Breast Milk May Protect against Necrotizing Enterocolitis
Studies Suggest that ErbB4 Receptor Activation May Be a Novel Therapeutic Avenue for Intestinal Diseases Involving Epithelial Cell Death, According to Research Published in The American Journal of Pathology
September 9, 2014

Researchers Identify Tests to Diagnose Invasive Aspergillosis with 100% Accuracy
Early, More Accurate Detection of This Potentially Deadly Fungus Can Improve Patient Outcomes, According to New Report in The Journal of Molecular Diagnostics
August 13, 2014

Gene That Controls Nerve Conduction Velocity Linked to Multiple Sclerosis
Evidence Found in Both Human Multiple Sclerosis Patients and Experimental Mouse Models, According to Research Published in The American Journal of Pathology.
August 13, 2014

New Class of Anti-Arthritis Drugs Effectively Treats Multiple Inflammatory Diseases
Commonly Prescribed Anti-Arthritics Can Exacerbate Other Inflammatory Diseases Like Periodontitis, According to New Research Published in The American Journal of Pathology
July 11, 2014

Biomarkers Accurately Distinguish Mesothelioma from Non-Cancerous Tissue Investigators Pinpoint Four Key MicroRNAs
According to New Report in The Journal of Molecular Diagnostics

June 6, 2014

New Research Provides Better Understanding of Endometriosis
Macrophages Present in Shed Endometrium in Mice May Suggest Key Role in Lesion Formation, According to New Research Published inThe American Journal of Pathology.
June 5, 2014

New Research Sets the Stage for Noninvasive Monitoring of HIV-Induced Peripheral Neuropathy
Corneal Nerve Fiber Assessment Proposed for Managing Patients with HIV-Induced Peripheral Neuropathy, According to The American Journal of Pathology
May 12, 2014

Adhesion Molecule Shows Promise for Treating Colitis
May Provide Therapeutic Target for Treating Inflammatory Bowel Disease and Preventing Colitis-Associated Colorectal Cancer, According to New Research Published in The American Journal of Pathology
April 28, 2014

Researchers Develop Novel Molecular Blood Group Typing Technique
New Technology Can Reduce Adverse Reactions and Decrease Blood Bank Costs, Report Investigators in The Journal of Molecular Diagnostics
April 10, 2014

Higher Levels of Cerebrospinal Fluid α-Synuclein Predict Faster Cognitive Loss in Parkinson Disease
Counterintuitive Findings Offer New Insights into Parkinson Disease Pathology, According to New Research Published in The American Journal of Pathology
March 11, 2014

Clues to Cancer Pathogenesis Found in Cell-Conditioned Media
Twenty Proteins Specifically Secreted by Primary Effusion Lymphoma (PEL) Cell Lines Identified, According to New Research Published in The American Journal of Pathology
February 10, 2014

Rett Syndrome Genetic Variants Now Publicly Available for Advance Testing, Diagnosis, and Research
Report Investigators in The Journal of Molecular Diagnostics
February 7, 2014

New Research May Boost Drug Efficacy in Treating Pulmonary Arterial Hypertension
Intravenous/Sublingual Tissue-Penetrating Homing Peptide Enhances Activity of Other Pulmonary Drugs, According to New Research Published in The American Journal of Pathology
Janiary 9, 2013


2013

Enzyme BACE1 May Be Important in Predicting Onset of Alzheimer Disease
Elevated BACE1 Activity in Mild Cognitive Impairment Could Be Early Indicator of Alzheimer Disease, According to New Research Published in The American Journal of Pathology
December 12, 2013

New Diagnostic Test Can Detect Chlamydia Trachomitis in Less Than 20 Minutes
Assay Offers Potential for High Sensitivity Testing at Point-of-Care Settings, Say Researchers in The Journal of Molecular Diagnostics
December 12, 2013

Transcription Factor May Protect Against Hepatic Injury Caused by Hepatitis C and Alcohol
More Damage Seen When FOXO3 Suppressed, According to Report in The American Journal of Pathology
November 11, 2013

Resveratrol, Found in Red Wine, Worsens MS-Like Symptoms and Neuropathology in Mice
Researchers Discourage Supplemental Use by Patients with Multiple Sclerosis, According to Report in The American Journal of Pathology
October 1, 2013

Novel Avian Influenza A Virus Has Potential for Both Virulence and Transmissibility in Humans
Virus Attaches to Both Upper and Lower Respiratory Tract Epithelium, According to Report in The American Journal of Pathology
September 10, 2013

Ovarian Cancer Metastases Influenced by Factors in Target Tissues
Both Milky Spots and Fat Cells in Omentum Promote Cancer Cell Migration, Growth, and Spread, Reports The American Journal of Pathology
July 18, 2013

Unraveling the Largest Outbreak of Fungal Infections Associated with Contaminated Steroid Injections
Findings Suggest Black Mold Targeting the Base of the Brain, Reports The American Journal of Pathology
June 26, 2013

Reversal Cells May Tip the Balance Between Bone Formation and Resorption in Health and Disease
Investigators Report on a Possible "Missing Link" in The American Journal of Pathology
June 6, 2013

New Study Pinpoints Biochemical Mechanism Underlying Fibrosis Following Glaucoma Surgery
Findings Suggest VEGF Inhibition via TGF-ß1 May Be Beneficial, Reports The American Journal of Pathology
May 17, 2013

New research examines connection between inflammatory stimulus and Parkinson's disease.
April 23, 2013pdf

Cell-Permeable Peptide Shows Promise for Controlling Cardiovascular Disease
Cell-Permeable Peptide Hampers Inflammation and Atherosclerosis in Mice, Report Investigators in The American Journal of Pathology
April 16, 2013

Study Points to Essential Role of IL-22 in Lung Repair After the Flu
Results of New Study Published in The American Journal of Pathology
March 11, 2013

Activation of Cortical Type 2 Cannabinoid Receptors Ameliorates Ischemic Brain Injury
Reported in The American Journal of Pathology
February 21, 2013

Tamoxifen Ameliorates Symptoms of Duchenne Muscular Dystrophy
Results of New Study Published in The American Journal of Pathology
January 15, 2013