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Erkki Ruoslahti MD PhD (Erkki
Ruoslahti's Biosketch)
The Burnham Inst
10901 N Torrey Pines Rd
La Jolla, CA 92037
ruoslahti@burnham.org
Vascular zipcodes in tumor angiogenesis and metastasis
Abstract:
Screening of phage libraries for peptides that can direct phage homing to
individual tissues in live mice has revealed an unprecedented extent of
diversity in the endothelia of various tissues and pathological lesions: (1)
The blood vessels in many, perhaps all, individual
tissues are distinct; (2) Tumor blood vessels differ from normal blood vessels;
(3) Tumor lymphatics express specific markers that are not present in normal
lymphatics or in the blood vessels of the same tumor; and (4) The vessels in
pre-malignant lesions are distinguishable from normal vessels and from vessels
in fully malignant tumors of the same type. The homing peptides can be used in
targeted deliver diagnostic probes and therapeutics. Some homing peptides have
their own intrinsic anti-angiogenic and anti-tumor activity. Finally,
tissue-specific vascular markers can serve as receptors for metastatic cells.
Recent publications:
Ruoslahti, E. Specialization of tumour vasculature. Nature Reviews Cancer
2: 83-90 (2002).
Christian, S., Pilch, J., Porkka, K., Laakkonen, P., and Ruoslahti, E.
Nucleoilin expressed at the cell surface is a marker of endothelial cells in
tumor blood vessels. J Cell Biol. 163: 871-878 (2003).
Hoffman, J.A., Giraudo E., Singh, M., Inoue, M., Porkka, K., Hanahan,
D., and Ruoslahti, E. Progressive vascular changes in a
transgenic mouse model of squamous cell carcinoma. Cancer Cell . 4:383-391
(2003).
Joyce, J.A., Laakkonen P., Bernasconi, M., Bergers, G., Ruoslahti,
E., and Hanahan, D. Stage-specific vascular markers revealed by phage display in
a mouse model of pancreatic islet tumorigenesis. Cancer Cell 4:393-403
(2003).
Laakkonen, P., Akerman, M.E., Biliran, H., Yang, M., Ferrer, F., Karpanen, T.,
Hoffman, R.M., and Ruoslahti, E. Antitumor activity of a homing peptide that
targets tumor lymphatics and tumor cells. Proc. Natl. Acad. Sci. USA.
101, 9381-9386 (2004).
Brown, D. and Ruoslahti, E. Metadherin, a novel cell-surface protein in breast
tumors that mediates lung metastasis. Cancer Cell 5: 365-374
(2004)
 Molecular and
Cellular Basis of Disease: Pathobiology of Neoplasia: Gateway to Improved
Prognosis
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