
A biosample
robot prepares specimens for testing. |
The pathologist uses diagnostic and screening
tests to identify and interpret the changes that characterize different
diseases in the cells, tissues, and fluids of the body. Anatomic
pathologists analyze the gross and microscopic structural changes caused by
disease in tissues and cells removed during surgery or at autopsy.
Cytopathology, the examination of individual cells to aid in disease
detection, is an important component of modern patient care.
Clinical
pathology encompasses chemistry, microbiology, immunology, hematology,
coagulation, and blood banking, among other types of laboratory testing.
Molecular pathology utilizes newly developed strategies for DNA and RNA
hybridization and amplification to aid in many aspects of both clinical and
anatomic diagnoses. Collectively, all the pathology specialties contribute
to understanding disease and treatment of the patient.
Pathologists participate in day-to-day care of patients by providing and
interpreting laboratory information to help solve diagnostic problems and to
monitor the effects of therapy. New tools are used to increase the precision
of diagnoses, e.g., those utilizing monoclonal antibodies, molecular
biology, image analysis, and flow cytometry. Because of the expanding volume
of new and highly complex tests, clinicians rely on the pathologist for
guidance and direction in use of the clinical laboratory and interpretation
of test results.
The new field of molecular diagnostics is particularly
rewarding, with techniques that permit identification of carriers of genetic
disease, diagnosis of viral and bacterial infections, monitoring of cancer
therapy, DNA fingerprinting for forensic (medico-legal) analysis, and
detection of cancer markers that assist in prognosis. For all pathologists,
clinical, anatomic, molecular, investigator or researcher, better patient
care is the ultimate goal. When unusual or unexpected abnormal results are
identified, and particularly when critical or life-threatening alterations
are found, the pathologist communicates directly with the patient's
physician.
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