ASIP Summer Research Opportunity Program in Pathology (SROPP)

Monte Willis, MD, PhD

Contact Information

Monte Willis, MD, PhD
103 Mason Farm Road
Chapel Hill, NC 27599-7525
Phone: (919) 843-1938
FAX: (919) 843-4585
monte_willis@med.unc.edu
http://www.med.unc.edu/pathology/faculty/biosketch-of-dr-monte-willis

Member of the Following FASEB Societies:

American Society for Investigative Pathology
The American Physiological Society

Program Description
Research in Dr. Willis' laboratory is focused on understanding novel molecular mechanisms involved in common cardiac diseases such as heart failure, ischemic heart disease, and genetic cardiomyopathies.

The laboratory investigates how the ubiquitin proteasome system (UPS) plays a role in regulating cardiac metabolism and protecting the heart against a variety of insults. More specifically, the laboratory studies how ubiquitin ligases are regulated by cardiac insults and how these factors mediate specific metabolic changes in turn to protect the heart by regulating energy metabolism and mitochondrial function.

The major research projects available in my laboratory include:

Investigating how components of the UPS are regulated in cardiac hypertrophy and ischemic injury.
Investigating the role of cardiomyocyte stretch in regulating the UPS components.
Determine the role of ubiquitin ligases in regulating energy metabolism and ATP production (via oxidative phosphorylation).

Reports from Previous Students:

Katelyn M. Williams, 2011

INTERESTED UNDERGRADUATE STUDENTS CONTACT:

Dr. Monte Willis - Email: monte_willis@med.unc.edu; Phone: 919-843-1938