ASIP Summer Research Opportunity Program in Pathology (SROPP)

Tim Oury, MD, PhD

Contact Information

Tim Oury, MD, PhD
Department of Pathology
W-952 BST
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-648-8519
Fax: 412-383-9594
tdoury@pitt.edu
http://path.upmc.edu/personnel/Faculty/Oury.htm

Member of the Following FASEB Societies:

American Society for Investigative Pathology
American Society for Biochemistry & Molecular Biology

Program Description

Research in Dr. Oury's lab is centered on understanding the molecular mechanisms involved in pulmonary fibrosis and acute interstitial lung disease.

The laboratory is investigating the role of extracellular oxidants in mediating physiologic and pathologic responses. The enzyme extracellular superoxide dismutase (EC-SOD) has been found to protect against pulmonary fibrosis and prevents inflammatory responses in the lung. The laboratory is investigating mechanisms by which EC-SOD mediates these responses.

Dr. Oury's laboratory is also investigating the role of the receptor for advanced glycation endproducts (RAGE) in mediating inflammatory and fibrotic responses in the lung. RAGE has been found to mediate pathologic responses in many disease models including diabetes and cancer. We have found that RAGE is highly expressed in the lung compared to other tissues and may mediate responses to many pulmonary injuries.

The major research projects available in my laboratory include:

1. Investigating the role of EC-SOD in pulmonary fibrosis.
2. Investigate the interaction of oxidants and proteinases in interstitial lung injury.
3. Investigate the role of RAGE in pulmonary fibrosis.
4. Mechanisms in Neurodegeneration and Learning and Memory.

Reports from Previous Students:
Kyle B. Wright, 2010

Interested Students Should Contact:
Dr. Tim Oury - Phone: 412-648-8519; tdoury@pitt.edu