American Society for Investigative Pathology, February 2012, Vol 4, No. 1

Dr. Lee will present his award lecture, "Mechanisms of TDP-43 Mediated Neurodegeneration in ALS and FTLD" on Saturday, April 21, 2012 at the ASIP Annual Meeting at Experimental Biology 2012 in San Diego, CA. He will receive the Excellence in Science Award on Monday, April 23, 2012 during the ASIP Awards Presentation and Membership Business Meeting.

Edward writes...

The American Society for Investigative Pathology has a long tradition of supporting biomedical scientists dedicated to studying the mechanisms of disease, and so I am honored to have been chosen to receive the 2012 ASIP Excellence in Science Award. I have been studying the molecular mechanisms underlying aging-related neurodegenerative diseases including Alzheimer’s disease, frontotemporal lobar dementia and amyotrophic lateral sclerosis. These are truly devastating diseases with limited treatment options, and we are confronted with the fact that the aging of the American people will only increase the physical, emotional and financial burden of neurodegenerative diseases.

As a member of ASIP since 2004, I have benefited from many discussions, networking opportunities, presentations, courses and meetings organized by ASIP for young scientists. Having served on its Membership Committee, I encourage other young scientists to become active, participating members of ASIP as we shape the future of experimental pathology. I thank the ASIP for this award and for its support over the years.




ASIP 2012 Excellence in Science Awardee

Edward LeeEdward B. Lee, MD, PhD, Recipient of ASIP 2012 Excellence in Science Award

Dr. Edward Lee has been selected as the 2012 recipient of the ASIP Excellence in Science Award, which recognizes outstanding achievement at the earliest stages of a career in biomedical research. Accomplishments include, but are not limited to, publications and presentations as well as volunteered service to the ASIP or other professional societies, institutional committees, and the pathology community. This award is funded through the generous support of the A.D. Sobel-ASIP Education Fund.

Dr. Lee received his MD, PhD from the University of Pennsylvania School of Medicine. The thesis work he completed involved looking at the molecular and cellular mechanisms of amyloid precursor protein production and developing conformation-selective monoclonal antibodies targeting amyloid oligomers as therapeutic agents for Alzheimer's disease.

According to Dr. John Tomaszewski, former Chair at the University of Pennsylvania School of Medicine and currently Chair of the Department of Pathology and Anatomic Sciences at Buffalo University School of Medicine, "Dr. Lee has been an outstanding example of a pathologist-scientist throughout his career, and he is a model of scientific success combined with kindhearted service to the academic community." Dr. Lee has "long been interested in aging, aging-related neurodegenerative diseases, and neuroscience." In addition, Dr. Tomaszewski states that Dr. Lee has continued on "a spectacular trajectory of research productivity and clinical prowess." Dr. Tomaszewski also quoted from Dr. Lee's clinical attendings' comments while he was in training at the University of Pennsylvania: Dr. Lee "is outstanding in every way," and "he is a wonderful trainee to work with. He is brilliant, well-organized, and caring. The neuropathology community has attracted a prize person."

Dr. Tomaszewski commends Dr. Lee for demonstrating excellence in the teaching of medical students and fellow residents, serving the academic community, serving as a section leader for several medical student classes, participating on the Membership Committee of the ASIP, and acting as co-chair for ASIP graduate student research sessions. Dr. Lee also volunteers his time for the University of Pennsylvania's Bioethics in Research course, gives lectures to staff in Neurology, Radiology, and Neurosurgery, and he generated a comprehensive Surgical Pathology manual to aid residents and fellows. "In short," states Dr. Tomaszewski, Dr. Lee "is one of the stars of the program."

According to Dr. John Trojanowski of University of Pennsylvania, Dr. Lee transitioned into his laboratory wanting to pursue "multiple projects related to neurodegenerative diseases" including studying the effects of TDP-43 protein expression on neuronal viability and gene expression in novel transgenic mice (TDP-43 is a protein found in intraneuronal and intraglial aggregates that play a key role in the pathogenesis of ALS and FTD), working on two completely different disease proteins, and branching out into endocrinology and metabolism research to study the role of obesity on AD. Dr. Trojanowski comments that Dr. Lee is "indefatigable in his voracious drive for science," and that "the pace of his research is accelerating."

Dr. Nicholas Gonatas of the University of Pennsylvania says that Dr. Lee is "among the top trainees within (a) prestigious group of individuals and" he is "confident that (Dr. Lee) will prove to be a leader in our field. Indeed, his publication record already tops 20 papers from highly respected journals."

Dr. Gonatas looks forward to witnessing Dr. Lee's continued success in science, stating that "his excitement for science" is "often infectious, and his intellectual curiosity is only matched by his hard work and diligence."